منابع مشابه
Activity and activation of the granulocyte superoxide-generating system.
Phagocytic cells generate superoxide (02 ) as a part of the respiratory burst of phagocytosis. We studied human granulocyte #{176}2 production in vitro in response to phorbol myristate acetate, a soluble fatty acid ester that stimulates 02 generation. The properties of this compound permit the adaptation of a continuous assay of 0 production to the study of the activity and activation (i.e., th...
متن کاملInhibitory effect of superoxide-generating quinones on superoxide dismutase.
The one-electron reduction of quinones to semiquinones and the subsequent autooxldatlon of the semlqulnone back to the quinone can generate large quantities of superoxide (0~) (1,2). This reductlon-oxldation process, known as redox cycling, is anion radical catalyzed by a variety of cellular flavoproteins and is thought to be responsible for many of the therapeutic and toxic effects of quinonoi...
متن کاملMetabolic activation of 1-naphthol and phenol by a simple superoxide-generating system and human leukocytes.
Phenol and 1-naphthol, products of benzene and naphthalene biotransformation, are metabolized during O2- generation by xanthine oxidase/hypoxanthine and phorbol myristate acetate (PMA)-stimulated human neutrophils. The addition of 1-naphthol to xanthine oxidase/hypoxanthine incubations resulted in the formation of 1,4-naphthoquinone (1,4-NQ) whereas phenol addition yielded only small quantities...
متن کاملDevelopment of the Superoxide-generating System during Differentiation of the HL-60 Human Promyelocytic Leukemia
Utilizing the induced differentiation of HL-60 promyelocytic leukemia cells as a model of myeloid maturation, we examined the development of the superoxide-generating system, focusing on NADPH oxidase activity, membrane depolarization, and cytochrome b content. NADPH oxidase activity, measured as NADPH-dependent superoxide production, increased with both spontaneous and N,N-dimethylformamideind...
متن کاملgp91-phox Gene Expression System in Leukocytes Via Controlling GCN5 Regulates the Superoxide-Generating
The superoxide anion (O 2 2)-generating system is an important mechanism of innate immune response against microbial infection in phagocytes and is involved in signal transduction mediated by various physiological and pathological signals in phagocytes and other cells, including B lymphocytes. The O 2 2-generating system is composed of five specific proteins: p22-phox, gp91-phox, p40-phox, p47-...
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2011
ISSN: 2153-2435
DOI: 10.4172/2153-2435.s1-002